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    The Discovery Screen has been designed to:

    Identify the effect of multiple additives on solubility and physical stability of the protein being formulated

    Assess the effect that different buffers and salts have on the protein in combination with the additives already identified to promote solubility and stability.

    10 of the top candidates will be chosen, based an several criteria, and solubility will be directly assessed.

    Discovery Screen

    The Discovery Screen begins to identify specific concentrations of additives identified in the Initial Screen that confer the desired effect on the protein of interest while minimizing adverse effects, such as unfolding of the protein, which would be detrimental to down stream structural and functional assays. As part of the Discovery Screen, a calorimetric analysis of the protein in the various solutions is performed to ensure that the protein has not lost its structure while in solution.

    As part of the Discovery Screen, a calorimetric analysis of the protein in the various solutions is performed to ensure that the protein has not lost its structure while in solution.